"However, when deciding how long to wait before becoming pregnant, patients and doctors should consider each woman's personal risk for recurrence, particularly for women who need adjuvant hormone therapy".
But a study of more than 1,200 women, presented on Saturday at the American Society of Clinical Oncology (ASCO) meeting in Chicago, now shows they may be able to have a baby without boosting the risk that their cancer will return. And, although half of newly-diagnosed women report interest in having children, Lambertini noted during a press briefing, less than 10 percent become pregnant following treatment (Cancer 2012;118 (6):1710-1717).
After about 10 years of follow-up, there was no significant difference in cancer recurrence between the women who had a baby and those who did not.
Aspirin appeared to be most beneficial in reducing the risk of colorectal cancers, with a 31% reduction in women and a 30% reduction in men. In 2013, the most recent year that data is available, more than 50,000 women were diagnosed with the disease. The researchers matched each patient who became pregnant with ones who did not but had similar tumor and treatment characteristics.
Uomini e Donne, Marco e Federica si sono già lasciati? Ecco l
Grazie per chi c'è, chi c'è stato e chi invece no, perché ho imparato l'importanza di avere le persone giuste nella mia vita. E' questa la notizia o, meglio, il dubbio che serpeggia al momento tra le menti dei fan di Uomini e donne .
When the researchers looked at the amount of time the women in the study breastfed, they found that breastfeeding for between 3 and 6 months correlated with a 7 percent reduced risk of uterine cancer compared to moms who never breastfed.
The primary endpoint was disease-free survival (DFS) in patients with ER-positive breast cancer. The median time from diagnosis to conception was 2.4 years. In women whose cancers were not fed by estrogen, those who became pregnant had a 42 percent lower chance of dying than those who did not, suggesting pregnancy may actually be protective against recurrence, Lambertini said. Researchers said their conclusions should allay concerns among some doctors and patients that pregnancy, which results in a surge in estrogen levels, could put these women at risk by encouraging the growth of any cancer cells that might remain in the body after treatment.
"Our findings should serve as strong basis for counseling women inquiring into the safety of future conception", said Lambertini. Of all survivors of cancer, those treated for breast cancer are the least likely to have children after diagnosis, ASCO added. "This long-term follow-up data that Dr. Lambertini has just presented provides a great reassurance for young breast cancer survivors and their doctor's that choosing to have a pregnancy after a breast cancer diagnosis is safe and acceptable to do". Further research on the effect of pregnancy on health outcomes of women with BRCA mutations, a group that typically develops the disease at the younger age, is also required. Pregnancy after ER-positive breast cancer is also sometimes discouraged because it requires survivors to temporarily stop taking postsurgical hormonal therapy that is meant to prevent recurrence.
Catlin Nalley is associate editor.