On the 21st minute there was a historic event in the history of football - the main referee Nestor Supply canceled goal Pepe, after consultation with videoassistance.
Within 15 minutes Portugal had taken the lead, however, with Ronaldo, who has now scored or provided an assist in each of his last seven games for the national team, nearly inevitably at the heart of it.
Substitute Cedric Soares looked like being the European champions' hero with his 86th-minute deflected shot, but Moreno's header from a corner spoiled the Southampton defender's celebration of his first global goal to snatch a 2-2 draw for Mexico.
Portugal play the hosts in Moscow on Wednesday before completing their group fixtures against New Zealand in Saint Petersburg on June 24.
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With time running out, Southampton right-back Cedric pounced on a loose ball and slammed home Portugal's second goal.
Mexico had to come back twice against Ronaldo and co. and a result like this will surely strengthen Osorio's belief that his team has learned many lessons since previous year.
While the VAR appeared to come to the correct decision, Santos was frustrated that this came only after the officials had looked at an earlier phase of play where Pepe was offside.
"The result was fair as Mexico also played well". Ronaldo magnificent pass found Quaresma, who is nobody to prevent to score into an empty net.
But the Portugal captain created another shooting opportunity for Quaresma with 10 minutes remaining and, although Ochoa saved comfortably, they continued to pile late pressure on Mexico.
Cristiano Ronaldo has now scored or assisted in each of his last seven games for Portugal.
Borussia Dortmund midfielder Raphael Guerreiro failed to deal with a cross into the box and Carlos Vela teed up Hernandez, who met the cross with a diving header. "We're very happy with this first game". They were second-best on the ball here, although they enjoyed the bulk of the chances and, on the balance of the second half, possibly deserved to win the game.