So she has reached three of the last nine Grand Slam finals, and on a women's tour big on depth and short on margins among rankings, that's a virtual dynasty (with Serena Williams an actual dynasty). She'll be hoping to get this match done in straight sets, and after beating Johanna Konta, she looks back to her best, although Muguruza is playing the best tennis since her victory at the French Open previous year.
If Venus, a five-time champion, succeeds at 37 she would be the oldest champion in 109 years.
Muguruza, who won the French Open a year ago, is aiming to become the first female Spanish player to win at Wimbledon since Conchita Martinez, her coach, in 1994. She floored World No 1 Angelique Kerber and then edged past Slovakian first-timer Magdalena Rybarikova to enter her second Wimbledon final.
Williams is bidding to win her sixth Wimbledon title, and first since 2008.
Williams, a five-time champion who had been trying to become the oldest victor of a major in the Open era, had squandered two set points at 5-4 in the first set.
You only have to look at Venus Williams's age  to see that Jo [who is 26] - a late bloomer in the women's game - potentially has another decade of chances.
It will be a gloomy two days at Wimbledon for finals weekend - and that is not because the Brits have been knocked out of the singles' tournaments. "I'm so close now, so I've just got to stay focused". "When she puts herself in a position to do that, she plays with a lot of depth, a lot of speed, and you don't get much of a chance to get your, I guess, grip into the points". I did play every week.
"The more experience you get, the more you know how to deal with these situations, because they're very special", she said.
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Muguruza had spoken eloquently this week of etching her name onto the Wimbledon honours board alongside Venus, Serena and the other All England Club icons. "I'm completely speechless. It's just - yeah, I mean, I'm just ..." a visibly shaken Williams said, before breaking down and walking out of the room.
The 37-year-old will take on 23-year-old Garbine Muguruza on Centre Court in front of a packed crowd.
Serena is not at Wimbledon this year because she is pregnant and taking the rest of the season off, but Venus will likely be checking in with her for some advice ahead of the match.
"I played very well for sure".
"I just try to hold my head up high, no matter what is happening in life".
"I think my mind is more equipped this time", said the 2016 French Open champion. "She's been really playing well on grass".
"I love the big stage", she said.
Last year BBC host John Inverdale congratulated Murray on becoming "the person ever to win two Olympic tennis gold medals", to which Murray shot back 'I think Venus and Serena have won about four each'.