The Bills dealt a sixth-round pick to the Rams as part of the Watkins trade.
The Rams have been searching all year for an outside vertical threat to complement new coach Sean McVay's offense and finally have that player in Watkins, who joins former Bills teammate Robert Woods in the Rams' wide receiver corps.
Here is a sampling of some of the funnier tweets about the trade.
It appears that the Bills are building for the future, as they now hold the Chiefs' 2018 first-round pick, the Rams' 2018 second-round pick, and the Eagles 2018 third-round pick. Instead, he has accepted the decision of general manager Brandon Beane and even thanked Buffalo for all the memories. However, Watkins was hobbled over the 2016 season with a foot injury. The Bills paid a hefty price to draft him in 2014, switching places with the Browns (No. 9 to No. 4) while also giving the Browns their 2015 first-round pick to ensure they could pick Watkins.
The Rams are betting on two things: that Watkins will stay healthy and play like the guy he was at Clemson, and that they can afford to keep him around long-term.
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The deals, however, involve more changes to a team with just 28 players who opened training camp on Buffalo's roster a year ago.
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Watkins' future in Buffalo was already in question after the Bills declined to pick up his fifth-year contract option in May.
Watkins has been dealing with a foot injury that limited the wide receiver to just eight games past year after having an operation to fix a broken foot.
Ultimately, though, this is a player who has per-16 game averages of 78 receptions, 930 yards and seven touchdowns through three seasons.
However, Matthews is still a talented receiver who could be effective in the upcoming season.
Darby started 29 games in his first two seasons in Buffalo.
That will give them at a minimum six selections in the top 100 of the draft, plus if they get any compensatory selection for the loss of Stephon Gillmore, and potentially four of those picks could be top 40 selections.
"I'm sure everybody was shocked", McCoy said. A separate deal with the Philadelphia Eagles saw the Bills getting a third-round pick next year in return for cornerback Ronald Darby. In 2015, he led 86 wide receivers with 50 or more targets in Reception Net Expected Points (NEP) per target at 1.05. - every time he was targeted, Buffalo gained over a full expected point.